| Registro completo |
| Provedor de dados: |
Biol. Res.
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| País: |
Chile
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| Título: |
Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents
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| Autores: |
Moraes de Carvalho,Katharinne I
Fernandes,Hélio B
Frota Machado,Flávia D
Oliveira,Irisdalva S
Oliveira,Francisco A
Nunes,Paulo Humberto M
Lima,Julianeli T
Silva Almeida,Jackson R G
Meneses Oliveira,Rita C
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| Data: |
2010-01-01
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| Ano: |
2010
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| Palavras-chave: |
Antioxidant
Antiulcer activity
Encholirium spectabile
Bromeliaceae
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| Resumo: |
This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53%), ethanol/HCl (75 %), ibuprofen (52 %) and ischemia/reperfusion (43 %). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective activity of the extract.
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| Tipo: |
Journal article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400011
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| Editor: |
Sociedad de Biología de Chile
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| Formato: |
text/html
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| Fonte: |
Biological Research v.43 n.4 2010
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